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Assay Detail

CHEMBL684383

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for its antagonist activity against calcium channel
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

1,4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach.
Coburn RA, Wierzba M, Suto MJ, Solo AJ, Triggle AM, Triggle DJ.
J Med Chem (1988) 31 : 2103 -2107
PubMed 2846838 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 8.54 10.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL292515 1 10.80
CHEMBL67067 1 10.49
CHEMBL24716 1 10.37
CHEMBL25676 1 9.97
CHEMBL63997 1 9.78
CHEMBL38597 1 9.30
CHEMBL293402 1 9.18
CHEMBL193 NIFEDIPINE 4.0 1 9.08
CHEMBL63764 1 8.71
CHEMBL25312 1 8.68
CHEMBL63743 1 8.67
CHEMBL292335 1 8.49
CHEMBL63030 1 8.44
CHEMBL288883 1 8.37
CHEMBL305316 1 7.87
CHEMBL2063842 1 7.85
CHEMBL304522 1 7.46
CHEMBL24419 1 7.28
CHEMBL294764 1 7.27
CHEMBL25934 1 7.18
CHEMBL1098881 1 6.52
CHEMBL63260 1 6.22
CHEMBL303436 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL292515 IC50 = 0.01585 nM 10.80
CHEMBL67067 IC50 = 0.03236 nM 10.49
CHEMBL24716 IC50 = 0.04266 nM 10.37
CHEMBL25676 IC50 = 0.1072 nM 9.97
CHEMBL63997 IC50 = 0.166 nM 9.78
CHEMBL38597 IC50 = 0.5012 nM 9.30
CHEMBL293402 IC50 = 0.6607 nM 9.18
CHEMBL193 NIFEDIPINE IC50 = 0.8318 nM 9.08
CHEMBL63764 IC50 = 1.95 nM 8.71
CHEMBL25312 IC50 = 2.089 nM 8.68
CHEMBL63743 IC50 = 2.138 nM 8.67
CHEMBL292335 IC50 = 3.236 nM 8.49
CHEMBL63030 IC50 = 3.631 nM 8.44
CHEMBL288883 IC50 = 4.266 nM 8.37
CHEMBL305316 IC50 = 13.49 nM 7.87
CHEMBL2063842 IC50 = 14.13 nM 7.85
CHEMBL304522 IC50 = 34.67 nM 7.46
CHEMBL24419 IC50 = 52.48 nM 7.28
CHEMBL294764 IC50 = 53.7 nM 7.27
CHEMBL25934 IC50 = 66.07 nM 7.18
CHEMBL1098881 IC50 = 302.0 nM 6.52
CHEMBL63260 IC50 = 602.56 nM 6.22
CHEMBL303436 IC50 > 10000.0 nM -