Compound Detail
CHEMBL25934
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Basic Information
| ChEMBL ID | CHEMBL25934 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZPBLGSLWZLGAP-VKAVYKQESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
315.4
MW (Da)
3.42
ALogP
5
HBA
1
HBD
68.1
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.18 | 7.18 | 66.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 66.07 | nM | 7.18 | Compound was tested for its antagonist activity against calcium channel | 2846838 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3746811 | 10.1021/jm00159a007 | Cytochrome P450 3A4 | 2 |
| 10377225 | 10.1021/jm981114c | Voltage-gated L-type calcium channel | 1 |
| 10377225 | 10.1021/jm981114c | ADMET | 1 |
| 7057416 | 10.1021/jm00344a007 | Cavia porcellus | 1 |
| 7057416 | 10.1021/jm00344a007 | Voltage-gated L-type calcium channel | 1 |
| 2846838 | 10.1021/jm00119a009 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine