Assay Detail
Functional
CHEMBL684428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the increase in [Ca2+] uptake into rat pituitary growth hormone3 (GH3) cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | GH3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.81 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93689 | — | — | 1 | 7.05 |
| CHEMBL327598 | — | — | 1 | 6.38 |
| CHEMBL420064 | — | — | 1 | 6.30 |
| CHEMBL330509 | — | — | 1 | 6.22 |
| CHEMBL327446 | — | — | 1 | 5.89 |
| CHEMBL94001 | — | — | 1 | 5.62 |
| CHEMBL93404 | — | — | 1 | 5.48 |
| CHEMBL327915 | — | — | 1 | 5.47 |
| CHEMBL316123 | — | — | 1 | 5.44 |
| CHEMBL93511 | — | — | 1 | 5.37 |
| CHEMBL92245 | — | — | 1 | 5.27 |
| CHEMBL93352 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93689 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL327598 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL420064 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL330509 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL327446 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL94001 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL93404 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL327915 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL316123 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL93511 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL92245 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL93352 | — | EC50 | = | 6200.0 | nM | 5.21 |