Assay Detail
Functional
CHEMBL684492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.54 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346030 | — | — | 1 | 7.50 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 7.14 |
| CHEMBL351934 | — | — | 1 | 7.00 |
| CHEMBL161007 | — | — | 1 | 6.89 |
| CHEMBL349025 | — | — | 1 | 6.82 |
| CHEMBL159273 | — | — | 1 | 6.70 |
| CHEMBL355824 | — | — | 1 | 6.50 |
| CHEMBL422538 | — | — | 1 | 6.38 |
| CHEMBL349066 | — | — | 1 | 6.21 |
| CHEMBL162134 | — | — | 1 | 6.14 |
| CHEMBL350949 | — | — | 1 | 6.00 |
| CHEMBL161748 | — | — | 1 | 5.89 |
| CHEMBL161670 | — | — | 1 | 5.84 |
| CHEMBL161189 | — | — | 1 | - |
| CHEMBL161364 | — | — | 1 | - |
| CHEMBL349844 | — | — | 1 | - |
| CHEMBL159651 | — | — | 1 | - |
| CHEMBL161419 | — | — | 1 | - |
| CHEMBL159311 | — | — | 1 | - |
| CHEMBL159841 | — | — | 1 | - |
| CHEMBL159935 | — | — | 1 | - |
| CHEMBL159708 | — | — | 1 | - |
| CHEMBL262517 | — | — | 1 | - |
| CHEMBL161088 | — | — | 1 | - |
| CHEMBL422710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346030 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL7303 | ARECOLINE | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL351934 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL161007 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL349025 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL159273 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL355824 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL422538 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL349066 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL162134 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL350949 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL161748 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL161670 | — | EC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL161189 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL161364 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL349844 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL159651 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL161419 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL159311 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL159841 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL159935 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL159708 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL262517 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL161088 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL422710 | — | EC50 | > | 30000.0 | nM | - |