Assay Detail
Binding
CHEMBL684568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]gastrin from guinea pig gastric glands
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cholecystokinin antagonists. Synthesis and biological evaluation of 4-substituted 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.84 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53907 | — | — | 1 | 8.15 |
| CHEMBL50986 | — | — | 1 | 7.19 |
| CHEMBL53234 | — | — | 1 | 6.42 |
| CHEMBL298705 | — | — | 1 | 6.42 |
| CHEMBL298948 | — | — | 1 | 5.62 |
| CHEMBL301172 | — | — | 1 | 5.52 |
| CHEMBL416483 | — | — | 1 | 5.32 |
| CHEMBL51569 | — | — | 1 | 4.92 |
| CHEMBL299538 | — | — | 1 | 4.60 |
| CHEMBL300926 | — | — | 1 | 4.22 |
| CHEMBL301331 | — | — | 1 | - |
| CHEMBL51280 | — | — | 1 | - |
| CHEMBL661 | ALPRAZOLAM | 4.0 | 1 | - |
| CHEMBL646 | TRIAZOLAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53907 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL50986 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL53234 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL298705 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL298948 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL301172 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL416483 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL51569 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL299538 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL300926 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL301331 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL51280 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL661 | ALPRAZOLAM | IC50 | > | 100000.0 | nM | - |
| CHEMBL646 | TRIAZOLAM | IC50 | > | 100000.0 | nM | - |