Compound Detail
CHEMBL300926
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CN(C)Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12
Basic Information
| ChEMBL ID | CHEMBL300926 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZTFOFQBUMXTOMC-XMMPIXPASA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
464.6
MW (Da)
5.08
ALogP
5
HBA
1
HBD
62.1
PSA (Ų)
0.39
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholecystokinin receptor type A CHEMBL2871 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
| Gastrin/cholecystokinin type B receptor CHEMBL298 | IC50 | 4.22 | 4.22 | 60000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cholecystokinin receptor type A | IC50 | = | 14000.0 | nM | 4.85 | Displacement of [125I]CCK from Cholecystokinin receptor of rat pancreas | 3336017 |
| Gastrin/cholecystokinin type B receptor | IC50 | = | 60000.0 | nM | 4.22 | Displacement of [125I]gastrin from guinea pig gastric glands | 3336017 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3336017 | 10.1021/jm00396a028 | Cholecystokinin receptor type A | 1 |
| 3336017 | 10.1021/jm00396a028 | Unchecked | 1 |
| 3336017 | 10.1021/jm00396a028 | Gastrin/cholecystokinin type B receptor | 1 |
Data from ChEMBL 36 via Core Engine