Assay Detail
Functional
CHEMBL684930
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Inhibition of human HCT-15 (human colon adenocarcinoma, MDR positive) cell growth
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.57 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.77 |
| CHEMBL295738 | — | — | 1 | 8.77 |
| CHEMBL45473 | — | — | 1 | 8.66 |
| CHEMBL297072 | — | — | 1 | 8.42 |
| CHEMBL296406 | — | — | 1 | 8.36 |
| CHEMBL295259 | — | — | 1 | 8.19 |
| CHEMBL45848 | — | — | 1 | 8.14 |
| CHEMBL297677 | — | — | 1 | 8.13 |
| CHEMBL296914 | — | — | 1 | 8.11 |
| CHEMBL45512 | — | — | 1 | 8.09 |
| CHEMBL297848 | — | — | 1 | 8.00 |
| CHEMBL46052 | — | — | 1 | 7.96 |
| CHEMBL295356 | — | — | 1 | 7.92 |
| CHEMBL47306 | — | — | 1 | 7.85 |
| CHEMBL46441 | — | — | 1 | 7.82 |
| CHEMBL296066 | — | — | 1 | 7.75 |
| CHEMBL295644 | — | — | 1 | 7.70 |
| CHEMBL295850 | — | — | 1 | 7.57 |
| CHEMBL49889 | — | — | 1 | 7.57 |
| CHEMBL295543 | — | — | 1 | 7.55 |
| CHEMBL297236 | — | — | 1 | 7.44 |
| CHEMBL45469 | — | — | 1 | 7.24 |
| CHEMBL301341 | — | — | 1 | 7.17 |
| CHEMBL45481 | — | — | 1 | 7.16 |
| CHEMBL297846 | — | — | 1 | 7.12 |
| CHEMBL45482 | — | — | 1 | 7.10 |
| CHEMBL47112 | — | — | 1 | 7.10 |
| CHEMBL46072 | — | — | 1 | 7.05 |
| CHEMBL46215 | — | — | 1 | 6.66 |
| CHEMBL46840 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL295738 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL45473 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL297072 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL296406 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL295259 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL45848 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL297677 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL296914 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL45512 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL297848 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL46052 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL295356 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL47306 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL46441 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL296066 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL295644 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL295850 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL49889 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL295543 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL297236 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL45469 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL301341 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL45481 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL297846 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL45482 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL47112 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL46072 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL46215 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL46840 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL297018 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL48004 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL295036 | — | IC50 | = | 7260.0 | nM | 5.14 |