Assay Detail
Binding
CHEMBL685131
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dexamethasone binding to human Glucocorticoid Receptor
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.17 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1473 | FLUTICASONE PROPIONATE | 4.0 | 1 | 9.30 |
| CHEMBL302366 | — | — | 2 | 8.47 |
| CHEMBL63241 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1473 | FLUTICASONE PROPIONATE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL302366 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL302366 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL63241 | — | IC50 | = | 194.0 | nM | 6.71 |