Assay Detail
Binding
CHEMBL685227
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The compound was tested for it's inhibitory activity against Onchocerca volvulus Glutathione S-transferase 2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Onchocerca volvulus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Beta-carbonyl substituted glutathione conjugates as inhibitors Of O. volvulus GST2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.58 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174893 | — | — | 1 | 5.39 |
| CHEMBL359933 | — | — | 1 | 5.08 |
| CHEMBL177327 | — | — | 1 | 4.72 |
| CHEMBL369465 | — | — | 1 | 4.50 |
| CHEMBL441308 | — | — | 1 | 4.39 |
| CHEMBL176294 | — | — | 1 | 4.32 |
| CHEMBL174957 | — | — | 1 | 4.18 |
| CHEMBL426936 | — | — | 1 | 4.05 |
| CHEMBL176946 | — | — | 1 | - |
| CHEMBL174379 | — | — | 1 | - |
| CHEMBL175098 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174893 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL359933 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL177327 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL369465 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL441308 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL176294 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL174957 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL426936 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL176946 | — | IC50 | = | 143300.0 | nM | - |
| CHEMBL174379 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL175098 | — | IC50 | = | 220000.0 | nM | - |