Assay Detail
Functional
CHEMBL685249
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Transcriptional activation in CV-1 cells expressing glucocorticoid receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.56 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.10 |
| CHEMBL97206 | — | — | 1 | 8.05 |
| CHEMBL99123 | — | — | 1 | 8.00 |
| CHEMBL317578 | — | — | 1 | 7.92 |
| CHEMBL330638 | — | — | 1 | 7.62 |
| CHEMBL327757 | — | — | 1 | 7.55 |
| CHEMBL100219 | — | — | 1 | 7.54 |
| CHEMBL95644 | — | — | 1 | 7.36 |
| CHEMBL419158 | — | — | 1 | 6.97 |
| CHEMBL99046 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL97206 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL99123 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL317578 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL330638 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL327757 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL100219 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL95644 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL419158 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL99046 | — | IC50 | = | 300.0 | nM | 6.52 |