Assay Detail
Binding
CHEMBL685311
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In vitro binding affinity of Gonadotropin-releasing hormone antagonist was measured in rat pituitary cell membranes
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Pituitary gland cell |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel gonadotropin-releasing hormone antagonists: peptides incorporating modified N omega-cyanoguanidino moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 17 | 9.28 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414113 | — | — | 1 | 10.10 |
| CHEMBL386314 | — | — | 1 | 9.96 |
| CHEMBL2369860 | — | — | 1 | 9.68 |
| CHEMBL414391 | — | — | 1 | 9.62 |
| CHEMBL218396 | — | — | 1 | 9.57 |
| CHEMBL269583 | — | — | 1 | 9.57 |
| CHEMBL438762 | — | — | 1 | 9.49 |
| CHEMBL261999 | — | — | 1 | 9.39 |
| CHEMBL438191 | — | — | 1 | 9.35 |
| CHEMBL2369851 | — | — | 1 | 9.32 |
| CHEMBL407482 | — | — | 1 | 9.00 |
| CHEMBL407023 | — | — | 1 | 8.92 |
| CHEMBL439359 | — | — | 1 | 8.92 |
| CHEMBL411586 | — | — | 1 | 8.89 |
| CHEMBL412802 | — | — | 1 | 8.77 |
| CHEMBL428837 | — | — | 1 | 8.68 |
| CHEMBL265522 | — | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414113 | — | Kd | = | 0.08 | nM | 10.10 |
| CHEMBL386314 | — | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL2369860 | — | Kd | = | 0.21 | nM | 9.68 |
| CHEMBL414391 | — | Kd | = | 0.24 | nM | 9.62 |
| CHEMBL218396 | — | Kd | = | 0.27 | nM | 9.57 |
| CHEMBL269583 | — | Kd | = | 0.27 | nM | 9.57 |
| CHEMBL438762 | — | Kd | = | 0.32 | nM | 9.49 |
| CHEMBL261999 | — | Kd | = | 0.41 | nM | 9.39 |
| CHEMBL438191 | — | Kd | = | 0.45 | nM | 9.35 |
| CHEMBL2369851 | — | Kd | = | 0.48 | nM | 9.32 |
| CHEMBL407482 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL407023 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL439359 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL411586 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL412802 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL428837 | — | Kd | = | 2.1 | nM | 8.68 |
| CHEMBL265522 | — | Kd | = | 3.3 | nM | 8.48 |