Assay Detail
Functional
CHEMBL685389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV replication in H9 cells.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Keto/enol epoxy steroids as HIV-1 Tat inhibitors: structure-activity relationships and pharmacophore localization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.50 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137919 | — | — | 1 | 6.52 |
| CHEMBL91609 | — | — | 1 | 6.22 |
| CHEMBL3137911 | — | — | 1 | 5.92 |
| CHEMBL3137916 | — | — | 1 | 5.85 |
| CHEMBL2373330 | — | — | 1 | 5.85 |
| CHEMBL3137913 | — | — | 1 | 5.80 |
| CHEMBL109492 | — | — | 1 | 5.68 |
| CHEMBL3137917 | — | — | 1 | 5.62 |
| CHEMBL3137910 | — | — | 1 | 5.62 |
| CHEMBL111424 | — | — | 1 | 5.57 |
| CHEMBL320506 | — | — | 1 | 5.48 |
| CHEMBL325765 | — | — | 1 | 5.48 |
| CHEMBL323490 | — | — | 1 | 5.37 |
| CHEMBL108485 | — | — | 1 | 5.28 |
| CHEMBL108427 | — | — | 1 | 5.19 |
| CHEMBL111446 | — | — | 1 | 5.07 |
| CHEMBL107878 | — | — | 1 | 5.03 |
| CHEMBL320265 | — | — | 1 | 4.99 |
| CHEMBL110573 | — | — | 1 | 4.96 |
| CHEMBL326009 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137919 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL91609 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3137911 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3137916 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2373330 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3137913 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL109492 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3137917 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3137910 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL111424 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL320506 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL325765 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL323490 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL108485 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL108427 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL111446 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL107878 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL320265 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL110573 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL326009 | — | IC50 | = | 25900.0 | nM | 4.59 |