Assay Detail
Binding
CHEMBL685520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested on a LS250B Perkin-Elmer fluorimeter for Growth factor receptor bound protein 2 equilibrium constant(Kd) by the Michaelis-Menten type curve-fitting equation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Growth factor receptor-bound protein 2 (CHEMBL3663) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.32 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142999 | — | — | 1 | 8.52 |
| CHEMBL77689 | — | — | 1 | 7.52 |
| CHEMBL3143002 | — | — | 1 | 7.35 |
| CHEMBL3143003 | — | — | 1 | 7.22 |
| CHEMBL3143006 | — | — | 1 | 7.22 |
| CHEMBL3142993 | — | — | 1 | 6.81 |
| CHEMBL3143004 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142999 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL77689 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL3143002 | — | Kd | = | 45.0 | nM | 7.35 |
| CHEMBL3143003 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL3143006 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL3142993 | — | Kd | = | 155.0 | nM | 6.81 |
| CHEMBL3143004 | — | Kd | = | 250.0 | nM | 6.60 |