Assay Detail
Binding
CHEMBL685573
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The compound was evaluated for its potency to inhibit the interaction between Growth factor receptor bound protein 2 and phosphotyrosine-containing peptides derived from Shc Y317
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Growth factor receptor-bound protein 2 (CHEMBL3663) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.76 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142999 | — | — | 1 | 7.96 |
| CHEMBL77689 | — | — | 1 | 6.92 |
| CHEMBL3143002 | — | — | 1 | 6.82 |
| CHEMBL3143003 | — | — | 1 | 6.70 |
| CHEMBL3143006 | — | — | 1 | 6.63 |
| CHEMBL3142993 | — | — | 1 | 6.30 |
| CHEMBL3143004 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142999 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL77689 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3143002 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3143003 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL3143006 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL3142993 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL3143004 | — | IC50 | = | 1098.0 | nM | 5.96 |