Assay Detail
Functional
CHEMBL685586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.59 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278920 | — | — | 1 | 7.72 |
| CHEMBL18265 | — | — | 1 | 7.60 |
| CHEMBL97541 | — | — | 1 | 7.44 |
| CHEMBL418551 | — | — | 1 | 7.10 |
| CHEMBL18558 | — | — | 1 | 6.92 |
| CHEMBL18081 | — | — | 1 | 6.85 |
| CHEMBL18864 | — | — | 1 | 6.70 |
| CHEMBL18471 | — | — | 1 | 6.62 |
| CHEMBL18309 | — | — | 1 | 6.60 |
| CHEMBL97287 | — | — | 1 | 6.60 |
| CHEMBL406006 | — | — | 1 | 6.56 |
| CHEMBL18177 | — | — | 1 | 6.55 |
| CHEMBL19106 | — | — | 1 | 6.40 |
| CHEMBL267475 | FPL-55712 | — | 1 | 6.29 |
| CHEMBL18703 | — | — | 1 | 6.22 |
| CHEMBL19281 | — | — | 1 | 6.10 |
| CHEMBL277292 | — | — | 1 | 6.10 |
| CHEMBL19136 | — | — | 1 | 6.00 |
| CHEMBL18775 | — | — | 1 | 5.70 |
| CHEMBL18490 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278920 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL18265 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL97541 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL418551 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL18558 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL18081 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL18864 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL18471 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL18309 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL97287 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL406006 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL18177 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL19106 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL267475 | FPL-55712 | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL18703 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL19281 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL277292 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL19136 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL18775 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL18490 | — | IC50 | = | 2000.0 | nM | 5.70 |