Assay Detail
Functional
CHEMBL685777
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In vitro antiproliferative activity against human carcinoma cell line HCT116 (colon)
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 5.79 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76326 | — | — | 1 | 6.77 |
| CHEMBL74637 | — | — | 1 | 6.77 |
| CHEMBL72076 | — | — | 1 | 6.76 |
| CHEMBL75368 | — | — | 1 | 6.70 |
| CHEMBL308979 | — | — | 1 | 6.38 |
| CHEMBL76464 | — | — | 1 | 6.35 |
| CHEMBL308541 | — | — | 1 | 6.24 |
| CHEMBL308099 | — | — | 1 | 6.17 |
| CHEMBL306748 | — | — | 1 | 6.12 |
| CHEMBL76337 | — | — | 1 | 6.11 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.07 |
| CHEMBL311851 | — | — | 1 | 6.05 |
| CHEMBL307219 | — | — | 1 | 6.00 |
| CHEMBL312292 | — | — | 1 | 6.00 |
| CHEMBL430606 | — | — | 1 | 5.98 |
| CHEMBL307152 | — | — | 1 | 5.98 |
| CHEMBL74289 | — | — | 1 | 5.97 |
| CHEMBL308594 | — | — | 1 | 5.95 |
| CHEMBL72069 | — | — | 1 | 5.95 |
| CHEMBL73742 | — | — | 1 | 5.92 |
| CHEMBL73764 | — | — | 1 | 5.91 |
| CHEMBL306856 | — | — | 1 | 5.90 |
| CHEMBL72754 | — | — | 1 | 5.87 |
| CHEMBL73794 | — | — | 1 | 5.86 |
| CHEMBL73751 | — | — | 1 | 5.84 |
| CHEMBL73485 | — | — | 1 | 5.84 |
| CHEMBL73718 | — | — | 1 | 5.83 |
| CHEMBL73781 | — | — | 1 | 5.81 |
| CHEMBL73343 | — | — | 1 | 5.79 |
| CHEMBL306047 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76326 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL74637 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL72076 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL75368 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308979 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL76464 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL308541 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL308099 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL306748 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL76337 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL311851 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL312292 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL307219 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL307152 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL430606 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL74289 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL308594 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL72069 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL73742 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL73764 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL306856 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL72754 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL73794 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL73485 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL73751 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL73718 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL73781 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL73343 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL306047 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL72077 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL306611 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL74883 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL306501 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL306034 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL307150 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL308116 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL307630 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL308252 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL441258 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL72661 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL75952 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL73772 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL75984 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL73413 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL310491 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL308479 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL72607 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL75610 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL73767 | — | IC50 | = | 3850.0 | nM | 5.42 |