Assay Detail
Functional
CHEMBL685779
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Tested for antiproliferative activity against HCT116 colorectal human carcinoma cell using WST-1 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.88 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27556 | — | — | 1 | 6.16 |
| CHEMBL26844 | — | — | 1 | 5.50 |
| CHEMBL283931 | — | — | 1 | 5.41 |
| CHEMBL275380 | — | — | 1 | 5.33 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.27 |
| CHEMBL26518 | — | — | 1 | 5.18 |
| CHEMBL26158 | — | — | 1 | 5.12 |
| CHEMBL283439 | — | — | 1 | 5.03 |
| CHEMBL28280 | — | — | 1 | 5.01 |
| CHEMBL285793 | — | — | 1 | 4.68 |
| CHEMBL433820 | — | — | 1 | 4.65 |
| CHEMBL25981 | — | — | 1 | 4.41 |
| CHEMBL27666 | — | — | 1 | 4.11 |
| CHEMBL27038 | — | — | 1 | 4.06 |
| CHEMBL287402 | — | — | 1 | 4.06 |
| CHEMBL283698 | — | — | 1 | 4.04 |
| CHEMBL280792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27556 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL26844 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL283931 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL275380 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL26518 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL26158 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL283439 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL28280 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL285793 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL433820 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL25981 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL27666 | — | IC50 | = | 77900.0 | nM | 4.11 |
| CHEMBL27038 | — | IC50 | = | 87200.0 | nM | 4.06 |
| CHEMBL287402 | — | IC50 | = | 87600.0 | nM | 4.06 |
| CHEMBL283698 | — | IC50 | = | 90100.0 | nM | 4.04 |
| CHEMBL280792 | — | IC50 | = | 112500.0 | nM | - |