Assay Detail
Binding
CHEMBL685886
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of geranylgeranyltransferase-1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl transferase type I (CHEMBL2095164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.73 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282161 | — | — | 1 | 6.27 |
| CHEMBL280847 | — | — | 1 | 6.22 |
| CHEMBL27677 | — | — | 1 | 5.89 |
| CHEMBL29633 | — | — | 1 | 5.89 |
| CHEMBL29503 | — | — | 1 | 5.85 |
| CHEMBL284637 | — | — | 1 | 5.82 |
| CHEMBL29980 | — | — | 1 | 5.80 |
| CHEMBL282166 | — | — | 1 | 5.57 |
| CHEMBL430073 | — | — | 1 | 5.40 |
| CHEMBL30059 | — | — | 1 | 5.35 |
| CHEMBL29499 | — | — | 1 | 5.00 |
| CHEMBL29619 | — | — | 1 | - |
| CHEMBL30118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282161 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL280847 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL27677 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL29633 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL29503 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL284637 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL29980 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL282166 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL430073 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL30059 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL29499 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL29619 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL30118 | — | IC50 | = | 161000.0 | nM | - |