Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL685935

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability to induce human glutamine synthetase in skeletal muscle cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Glutamine synthetase (CHEMBL4612)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
Ali A, Thompson CF, Balkovec JM, Graham DW, Hammond ML, Quraishi N, Tata JR, Einstein M, Ge L, Harris G, Kelly TM, Mazur P, Pandit S, Santoro J, Sitlani A, Wang C, Williamson J, Miller DK, Thompson CM, Zaller DM, Forrest MJ, Carballo-Jane E, Luell S.
J Med Chem (2004) 47 : 2441 -2452
PubMed 15115388 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 7.25 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL310570 1 7.85
CHEMBL131 PREDNISOLONE 4.0 1 7.50
CHEMBL83110 1 7.42
CHEMBL82546 1 7.27
CHEMBL309243 1 7.18
CHEMBL312399 1 7.18
CHEMBL311662 1 6.89
CHEMBL312041 1 6.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL310570 EC50 = 14.2 nM 7.85
CHEMBL131 PREDNISOLONE EC50 = 32.0 nM 7.50
CHEMBL83110 EC50 = 37.7 nM 7.42
CHEMBL82546 EC50 = 53.7 nM 7.27
CHEMBL309243 EC50 = 66.0 nM 7.18
CHEMBL312399 EC50 = 66.0 nM 7.18
CHEMBL311662 EC50 = 129.2 nM 6.89
CHEMBL312041 EC50 = 181.6 nM 6.74