Assay Detail
Binding
CHEMBL685962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory against Gamma-aminobutyric acid A receptor from rat cerebral cortex using [3H]flunitrazepam as the radioligand
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2-a]benzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.66 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290683 | — | — | 1 | 8.96 |
| CHEMBL39653 | — | — | 1 | 8.96 |
| CHEMBL418240 | — | — | 1 | 8.85 |
| CHEMBL289181 | — | — | 1 | 8.72 |
| CHEMBL284301 | — | — | 1 | 8.46 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.31 |
| CHEMBL39147 | — | — | 1 | 8.29 |
| CHEMBL290520 | — | — | 1 | 8.21 |
| CHEMBL39831 | — | — | 1 | 8.20 |
| CHEMBL39196 | — | — | 1 | 8.20 |
| CHEMBL289414 | — | — | 1 | 8.15 |
| CHEMBL287783 | — | — | 1 | 8.11 |
| CHEMBL289107 | — | — | 1 | 8.08 |
| CHEMBL290196 | — | — | 1 | 8.00 |
| CHEMBL290298 | — | — | 1 | 7.98 |
| CHEMBL38740 | — | — | 1 | 7.85 |
| CHEMBL288962 | — | — | 1 | 7.77 |
| CHEMBL38684 | — | — | 1 | 7.75 |
| CHEMBL416061 | — | — | 1 | 7.70 |
| CHEMBL284856 | — | — | 1 | 7.52 |
| CHEMBL291258 | — | — | 1 | 7.52 |
| CHEMBL39428 | — | — | 1 | 7.40 |
| CHEMBL38622 | — | — | 1 | 7.39 |
| CHEMBL38549 | — | — | 1 | 7.18 |
| CHEMBL434597 | — | — | 1 | 7.18 |
| CHEMBL38490 | — | — | 1 | 7.02 |
| CHEMBL289328 | — | — | 1 | 6.81 |
| CHEMBL40077 | — | — | 1 | 6.81 |
| CHEMBL445834 | — | — | 1 | 6.76 |
| CHEMBL288203 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290683 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL39653 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL418240 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL289181 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL284301 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL12 | DIAZEPAM | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL39147 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL290520 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL39831 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL39196 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL289414 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL287783 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL289107 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL290196 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL290298 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL38740 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL288962 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL38684 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL416061 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL284856 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL291258 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL39428 | — | IC50 | = | 39.5 | nM | 7.40 |
| CHEMBL38622 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL38549 | — | IC50 | = | 66.2 | nM | 7.18 |
| CHEMBL434597 | — | IC50 | = | 65.6 | nM | 7.18 |
| CHEMBL38490 | — | IC50 | = | 96.3 | nM | 7.02 |
| CHEMBL289328 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL40077 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL445834 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL288203 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL288378 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL290687 | — | IC50 | = | 857.0 | nM | 6.07 |
| CHEMBL289707 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL290259 | — | IC50 | > | 1000.0 | nM | - |