Assay Detail
Functional
CHEMBL686190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1-p24 antigen production in monocyte-macrophages (in vitro anti-HIV-1 activity)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.93 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105916 | — | — | 1 | 8.70 |
| CHEMBL418812 | — | — | 1 | 8.40 |
| CHEMBL322698 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105916 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL418812 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL322698 | — | EC50 | = | 200.0 | nM | 6.70 |