Assay Detail
Binding
CHEMBL686306
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Inhibition against human glycogen synthase kinase-3alpha (hGSK-3).
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.83 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258483 | — | — | 1 | 8.30 |
| CHEMBL264161 | — | — | 1 | 8.15 |
| CHEMBL407002 | — | — | 1 | 7.96 |
| CHEMBL407373 | — | — | 1 | 7.75 |
| CHEMBL261596 | — | — | 1 | 7.72 |
| CHEMBL263907 | — | — | 1 | 7.70 |
| CHEMBL407003 | — | — | 1 | 7.57 |
| CHEMBL406701 | — | — | 1 | 7.37 |
| CHEMBL258701 | — | — | 1 | 7.25 |
| CHEMBL406062 | — | — | 1 | 6.77 |
| CHEMBL260329 | — | — | 1 | 6.62 |
| CHEMBL260135 | — | — | 1 | 6.60 |
| CHEMBL288448 | — | — | 1 | 6.54 |
| CHEMBL264162 | — | — | 1 | 6.45 |
| CHEMBL261439 | — | — | 1 | 6.37 |
| CHEMBL261264 | — | — | 1 | 6.35 |
| CHEMBL408634 | — | — | 1 | 6.28 |
| CHEMBL261052 | — | — | 1 | 6.07 |
| CHEMBL259925 | — | — | 1 | 5.90 |
| CHEMBL407374 | — | — | 1 | 5.63 |
| CHEMBL408809 | — | — | 1 | 5.55 |
| CHEMBL287731 | — | — | 1 | 5.45 |
| CHEMBL428968 | — | — | 1 | - |
| CHEMBL40493 | — | — | 1 | - |
| CHEMBL290147 | — | — | 1 | - |
| CHEMBL40835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258483 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL264161 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL407002 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL407373 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL261596 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL263907 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL407003 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL406701 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL258701 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL406062 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL260329 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL260135 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL288448 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL264162 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL261439 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL261264 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL408634 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL261052 | — | IC50 | = | 851.0 | nM | 6.07 |
| CHEMBL259925 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL407374 | — | IC50 | = | 2345.0 | nM | 5.63 |
| CHEMBL408809 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL287731 | — | IC50 | = | 3572.0 | nM | 5.45 |
| CHEMBL428968 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL40493 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL290147 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL40835 | — | IC50 | > | 5000.0 | nM | - |