Assay Detail
Binding
CHEMBL686307
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Inhibition of human glycogen synthase kinase-3alpha (hGSK-3)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.60 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288143 | — | — | 1 | 8.40 |
| CHEMBL41783 | — | — | 1 | 8.30 |
| CHEMBL259271 | — | — | 1 | 8.30 |
| CHEMBL261518 | — | — | 1 | 8.30 |
| CHEMBL264161 | — | — | 1 | 8.15 |
| CHEMBL261549 | — | — | 1 | 8.15 |
| CHEMBL409738 | — | — | 1 | 8.15 |
| CHEMBL406125 | — | — | 1 | 8.05 |
| CHEMBL261441 | — | — | 1 | 7.96 |
| CHEMBL259744 | — | — | 1 | 7.66 |
| CHEMBL258701 | — | — | 1 | 7.25 |
| CHEMBL261366 | — | — | 1 | 7.00 |
| CHEMBL260135 | — | — | 1 | 6.60 |
| CHEMBL261127 | — | — | 1 | 6.16 |
| CHEMBL261661 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288143 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL41783 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL259271 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL261518 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL264161 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL261549 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL409738 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL406125 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL261441 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL259744 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL258701 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL261366 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL260135 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL261127 | — | IC50 | = | 691.0 | nM | 6.16 |
| CHEMBL261661 | — | IC50 | = | 2697.0 | nM | 5.57 |