Assay Detail
Binding
CHEMBL686311
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Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha
74
Total Activities
74
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 74 | 4.34 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322970 | — | — | 1 | 6.98 |
| CHEMBL352222 | — | — | 1 | 4.70 |
| CHEMBL158885 | — | — | 1 | 4.28 |
| CHEMBL422714 | — | — | 1 | 4.24 |
| CHEMBL345348 | — | — | 1 | 4.23 |
| CHEMBL345801 | — | — | 1 | 4.16 |
| CHEMBL347681 | — | — | 1 | 4.15 |
| CHEMBL345212 | — | — | 1 | 4.13 |
| CHEMBL156987 | — | — | 1 | 4.12 |
| CHEMBL159149 | — | — | 1 | 4.10 |
| CHEMBL345800 | — | — | 1 | 4.09 |
| CHEMBL346721 | — | — | 1 | 4.08 |
| CHEMBL349810 | — | — | 1 | 4.07 |
| CHEMBL347134 | — | — | 1 | 4.04 |
| CHEMBL160333 | — | — | 1 | 4.03 |
| CHEMBL157258 | — | — | 1 | 4.03 |
| CHEMBL434484 | — | — | 1 | - |
| CHEMBL435045 | — | — | 1 | - |
| CHEMBL158835 | — | — | 1 | - |
| CHEMBL157348 | — | — | 1 | - |
| CHEMBL158719 | — | — | 1 | - |
| CHEMBL160937 | — | — | 1 | - |
| CHEMBL351801 | — | — | 1 | - |
| CHEMBL160829 | — | — | 1 | - |
| CHEMBL156801 | — | — | 1 | - |
| CHEMBL350029 | — | — | 1 | - |
| CHEMBL351342 | — | — | 1 | - |
| CHEMBL347647 | — | — | 1 | - |
| CHEMBL160251 | — | — | 1 | - |
| CHEMBL347580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322970 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL352222 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL158885 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL422714 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL345348 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL345801 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL347681 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL345212 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL156987 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL159149 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL345800 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL346721 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL349810 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL347134 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL157258 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL160333 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL350702 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL347632 | — | IC50 | = | 186000.0 | nM | - |
| CHEMBL160876 | — | IC50 | = | 109000.0 | nM | - |
| CHEMBL346107 | — | IC50 | = | 460000.0 | nM | - |
| CHEMBL345364 | — | IC50 | = | 134000.0 | nM | - |
| CHEMBL160598 | — | IC50 | = | 243000.0 | nM | - |
| CHEMBL156277 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL160938 | — | IC50 | = | 447000.0 | nM | - |
| CHEMBL160373 | — | IC50 | = | 472000.0 | nM | - |
| CHEMBL346493 | — | IC50 | = | 195000.0 | nM | - |
| CHEMBL156807 | — | IC50 | = | 390000.0 | nM | - |
| CHEMBL350435 | — | IC50 | = | 704000.0 | nM | - |
| CHEMBL155680 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL348505 | — | IC50 | = | 291000.0 | nM | - |
| CHEMBL349540 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL156563 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL158781 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL156801 | — | IC50 | = | 1398000.0 | nM | - |
| CHEMBL434484 | — | IC50 | = | 404000.0 | nM | - |
| CHEMBL435045 | — | IC50 | = | 2285000.0 | nM | - |
| CHEMBL158835 | — | IC50 | = | 392000.0 | nM | - |
| CHEMBL157348 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL158719 | — | IC50 | = | 131000.0 | nM | - |
| CHEMBL160937 | — | IC50 | = | 374000.0 | nM | - |
| CHEMBL351801 | — | IC50 | = | 1478000.0 | nM | - |
| CHEMBL160829 | — | IC50 | = | 481000.0 | nM | - |
| CHEMBL156808 | — | IC50 | = | 317000.0 | nM | - |
| CHEMBL350029 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL351342 | — | IC50 | = | 529000.0 | nM | - |
| CHEMBL347647 | — | IC50 | = | 216000.0 | nM | - |
| CHEMBL160251 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL347580 | — | IC50 | = | 694000.0 | nM | - |
| CHEMBL346523 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL346551 | — | IC50 | = | 529000.0 | nM | - |