Assay Detail
Functional
CHEMBL686362
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Inhibition of HCT116 (transformed colon) cell proliferation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.59 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48614 | — | — | 1 | 4.70 |
| CHEMBL46181 | — | — | 1 | 4.61 |
| CHEMBL45477 | — | — | 1 | 4.45 |
| CHEMBL48362 | — | — | 1 | - |
| CHEMBL51709 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48614 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL46181 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL45477 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL48362 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL51709 | — | IC50 | > | 50000.0 | nM | - |