Assay Detail
Functional
CHEMBL686366
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Toxicity tested against transformed human colon cancer cell line (HCT116)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.32 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345525 | — | — | 1 | 7.82 |
| CHEMBL357770 | — | — | 1 | 7.70 |
| CHEMBL358102 | — | — | 1 | 7.55 |
| CHEMBL148889 | — | — | 1 | 7.33 |
| CHEMBL346164 | — | — | 1 | 7.24 |
| CHEMBL149834 | — | — | 1 | 7.16 |
| CHEMBL147290 | — | — | 1 | 6.42 |
| CHEMBL148580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345525 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL357770 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL358102 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL148889 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL346164 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL149834 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL147290 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL148580 | — | IC50 | > | 900.0 | nM | - |