Assay Detail
Functional
CHEMBL686403
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In vitro cytotoxicity against human tumor cell line HEC-1-B
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEC-1B |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.56 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.22 |
| CHEMBL419007 | — | — | 1 | 6.72 |
| CHEMBL420670 | — | — | 1 | 6.17 |
| CHEMBL108508 | — | — | 1 | 5.68 |
| CHEMBL111658 | — | — | 1 | 5.57 |
| CHEMBL109188 | — | — | 1 | 5.48 |
| CHEMBL441645 | — | — | 1 | 5.46 |
| CHEMBL107773 | — | — | 1 | 5.44 |
| CHEMBL109103 | — | — | 1 | 5.44 |
| CHEMBL109181 | — | — | 1 | 5.33 |
| CHEMBL108027 | — | — | 1 | 5.22 |
| CHEMBL322998 | — | — | 1 | 5.00 |
| CHEMBL432606 | — | — | 1 | 4.92 |
| CHEMBL109029 | — | — | 1 | 4.89 |
| CHEMBL109521 | — | — | 1 | 4.83 |
| CHEMBL321011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL419007 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL420670 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL108508 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL111658 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL109188 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL441645 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL107773 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL109103 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL109181 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL108027 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL322998 | — | IC50 | = | 10050.0 | nM | 5.00 |
| CHEMBL432606 | — | IC50 | = | 12120.0 | nM | 4.92 |
| CHEMBL109029 | — | IC50 | = | 12830.0 | nM | 4.89 |
| CHEMBL109521 | — | IC50 | = | 14830.0 | nM | 4.83 |
| CHEMBL321011 | — | IC50 | > | 100000.0 | nM | - |