Assay Detail

CHEMBL686473

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibition of HCT116 human colon carcinoma cell proliferation

ChEMBL ↗

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Target

HCT-116 (CHEMBL394) ↗

Open DB target context

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HCT-116 (CHEMBL394) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HCT-116

CHEMBL394

Anchored from Assay target.

Protein identity HCT-116

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HCT-116
Confidence	1 — Organism
Curated By	Expert

Target

HCT-116 (CHEMBL394) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.

Barvian M, Boschelli DH, Cossrow J, Dobrusin E, Fattaey A, Fritsch A, Fry D, Harvey P, Keller P, Garrett M, La F, Leopold W, McNamara D, Quin M, Trumpp-Kallmeyer S, Toogood P, Wu Z, Zhang E.
J Med Chem (2000) 43 : 4606 -4616
PubMed 11101352 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.67	6.67

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL139653	—	—	1	6.67

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL139653	—	IC50	=	213.0	nM	6.67