Assay Detail
Functional
CHEMBL686474
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Inhibitory activity against colon tumor cell line HCT116 after 72 hr continuous exposure to compound
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.40 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 5.05 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 4.62 |
| CHEMBL47665 | — | — | 1 | 4.12 |
| CHEMBL48010 | — | — | 1 | 4.12 |
| CHEMBL47461 | — | — | 1 | 4.10 |
| CHEMBL45742 | — | — | 1 | - |
| CHEMBL48076 | — | — | 1 | - |
| CHEMBL298459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL47665 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL48010 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL47461 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL45742 | — | IC50 | = | 195000.0 | nM | - |
| CHEMBL48076 | — | IC50 | = | 266000.0 | nM | - |
| CHEMBL298459 | — | IC50 | = | 143000.0 | nM | - |