Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL686480

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against human colon cancer HCT116 cell proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Expert

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Histone deacetylase inhibitors.
Miller TA, Witter DJ, Belvedere S.
J Med Chem (2003) 46 : 5097 -5116
PubMed 14613312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 5.27 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 6.00
CHEMBL98346 1 5.70
CHEMBL98345 1 5.70
CHEMBL317814 1 5.52
CHEMBL97387 1 5.40
CHEMBL97860 1 5.10
CHEMBL100035 1 4.82
CHEMBL319248 1 4.66
CHEMBL97632 1 4.52
CHEMBL97108 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN EC50 = 1000.0 nM 6.00
CHEMBL98346 EC50 = 2000.0 nM 5.70
CHEMBL98345 EC50 = 2000.0 nM 5.70
CHEMBL317814 EC50 = 3000.0 nM 5.52
CHEMBL97387 EC50 = 4000.0 nM 5.40
CHEMBL97860 EC50 = 8000.0 nM 5.10
CHEMBL100035 EC50 = 15000.0 nM 4.82
CHEMBL319248 EC50 = 22000.0 nM 4.66
CHEMBL97632 EC50 = 30000.0 nM 4.52
CHEMBL97108 EC50 > 50000.0 nM -