Assay Detail
Functional
CHEMBL686482
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Concentration required to inhibit the HCT116 cell growth by 50%.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2000089 | TRAPOXIN B | — | 1 | 8.70 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.89 |
| CHEMBL140000 | — | — | 1 | 6.68 |
| CHEMBL143047 | — | — | 1 | 6.30 |
| CHEMBL57107 | — | — | 1 | 5.98 |
| CHEMBL162423 | — | — | 1 | 5.76 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.72 |
| CHEMBL164872 | — | — | 1 | 5.70 |
| CHEMBL165162 | — | — | 1 | 5.27 |
| CHEMBL353581 | PYROXAMIDE | 1.0 | 1 | 5.19 |
| CHEMBL349015 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2000089 | TRAPOXIN B | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL140000 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL143047 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL57107 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL162423 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL164872 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL165162 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL353581 | PYROXAMIDE | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL349015 | — | IC50 | > | 10000.0 | nM | - |