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Assay Detail

CHEMBL686597

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Binding
Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Growth factor receptor-bound protein 2 (CHEMBL3663)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic.
Gao Y, Luo J, Yao ZJ, Guo R, Zou H, Kelley J, Voigt JH, Yang D, Burke TR.
J Med Chem (2000) 43 : 911 -920
PubMed 10715157 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.66 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL367037 1 8.70
CHEMBL72036 1 8.40
CHEMBL279961 1 8.10
CHEMBL368263 1 7.92
CHEMBL19417 1 7.70
CHEMBL55627 1 7.30
CHEMBL303150 1 7.16
CHEMBL355776 1 6.80
CHEMBL353708 1 6.77
CHEMBL443564 1 6.17
CHEMBL355066 1 6.00
CHEMBL171244 1 5.96
CHEMBL355701 1 5.56
CHEMBL355777 1 5.19
CHEMBL174418 1 4.72
CHEMBL172088 1 4.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL367037 IC50 = 2.0 nM 8.70
CHEMBL72036 IC50 = 4.0 nM 8.40
CHEMBL279961 IC50 = 8.0 nM 8.10
CHEMBL368263 IC50 = 12.0 nM 7.92
CHEMBL19417 IC50 = 20.0 nM 7.70
CHEMBL55627 IC50 = 50.0 nM 7.30
CHEMBL303150 IC50 = 70.0 nM 7.16
CHEMBL355776 IC50 = 160.0 nM 6.80
CHEMBL353708 IC50 = 170.0 nM 6.77
CHEMBL443564 IC50 = 680.0 nM 6.17
CHEMBL355066 IC50 = 1000.0 nM 6.00
CHEMBL171244 IC50 = 1100.0 nM 5.96
CHEMBL355701 IC50 = 2750.0 nM 5.56
CHEMBL355777 IC50 = 6400.0 nM 5.19
CHEMBL174418 IC50 = 19000.0 nM 4.72
CHEMBL172088 IC50 = 68000.0 nM 4.17