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Assay Detail

CHEMBL686814

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against H+/K+ ATPase from pig stomach by probit analysis
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Tissue Stomach
Confidence 9 — Direct single protein target
Curated By Expert

Target

Potassium-transporting ATPase alpha chain 1 (CHEMBL3919)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

2-[(2-pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K(+)-ATPase inhibitors.
Weidmann K, Herling AW, Lang HJ, Scheunemann KH, Rippel R, Nimmesgern H, Scholl T, Bickel M, Metzger H.
J Med Chem (1992) 35 : 438 -450
PubMed 1310742 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.53 6.30
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL137943 1 6.30
CHEMBL140604 1 5.70
CHEMBL140688 1 5.70
CHEMBL138555 1 5.52
CHEMBL139225 1 5.40
CHEMBL344250 1 5.16
CHEMBL139433 1 4.92
CHEMBL138559 1 -
CHEMBL334908 1 -
CHEMBL138420 1 -
CHEMBL342046 1 -
CHEMBL139537 1 -
CHEMBL343109 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL137943 IC50 = 500.0 nM 6.30
CHEMBL140604 IC50 = 2000.0 nM 5.70
CHEMBL140688 IC50 = 2000.0 nM 5.70
CHEMBL138555 IC50 = 3000.0 nM 5.52
CHEMBL139225 IC50 = 4000.0 nM 5.40
CHEMBL344250 IC50 = 7000.0 nM 5.16
CHEMBL139433 IC50 = 12000.0 nM 4.92
CHEMBL138559 IC50 = - nM -
CHEMBL334908 IC50 = - nM -
CHEMBL138420 Inhibition = -77.0 % -
CHEMBL342046 IC50 = - nM -
CHEMBL139537 IC50 = - nM -
CHEMBL343109 IC50 = - nM -