Assay Detail
Functional
CHEMBL686876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranes.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.63 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127877 | — | — | 1 | 8.52 |
| CHEMBL340726 | — | — | 1 | 7.82 |
| CHEMBL123577 | — | — | 1 | 7.41 |
| CHEMBL126859 | — | — | 1 | 7.27 |
| CHEMBL128010 | — | — | 1 | 7.01 |
| CHEMBL125799 | — | — | 1 | 6.57 |
| CHEMBL125027 | — | — | 1 | 6.32 |
| CHEMBL125978 | — | — | 1 | 6.30 |
| CHEMBL8747 | REV-5901 | — | 1 | 6.29 |
| CHEMBL414242 | — | — | 1 | 6.25 |
| CHEMBL127530 | — | — | 1 | 6.24 |
| CHEMBL126379 | — | — | 1 | 6.00 |
| CHEMBL125139 | — | — | 1 | 5.84 |
| CHEMBL124760 | — | — | 1 | 5.82 |
| CHEMBL124709 | — | — | 1 | 5.75 |
| CHEMBL127545 | — | — | 1 | - |
| CHEMBL339304 | — | — | 1 | - |
| CHEMBL127905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127877 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL340726 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL123577 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL126859 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL128010 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL125799 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL125027 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL125978 | — | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL8747 | REV-5901 | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL414242 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL127530 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL126379 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL125139 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL124760 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL124709 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL127545 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL339304 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL127905 | — | IC50 | > | 50000.0 | nM | - |