Assay Detail
Functional
CHEMBL686880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Iks current in isolated guinea pig myocytes during a 1s voltage clamp step from -50 to +50 mV.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.08 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332826 | — | — | 1 | 8.22 |
| CHEMBL126716 | — | — | 1 | 8.22 |
| CHEMBL16900 | L-768673 | — | 1 | 8.22 |
| CHEMBL127701 | — | — | 1 | 8.05 |
| CHEMBL441474 | — | — | 1 | 8.00 |
| CHEMBL340353 | — | — | 1 | 8.00 |
| CHEMBL127661 | — | — | 1 | 7.96 |
| CHEMBL443550 | — | — | 1 | 7.85 |
| CHEMBL126421 | — | — | 1 | 7.70 |
| CHEMBL339327 | — | — | 1 | 7.52 |
| CHEMBL331861 | — | — | 1 | 7.46 |
| CHEMBL127423 | — | — | 1 | 7.35 |
| CHEMBL341044 | — | — | 1 | 7.22 |
| CHEMBL330992 | — | — | 1 | 6.96 |
| CHEMBL124092 | — | — | 1 | 6.85 |
| CHEMBL124993 | — | — | 1 | 6.70 |
| CHEMBL9387 | L-365260 | — | 1 | 6.67 |
| CHEMBL124306 | — | — | 1 | 6.52 |
| CHEMBL128007 | — | — | 1 | 6.28 |
| CHEMBL128031 | — | — | 1 | 6.22 |
| CHEMBL330970 | — | — | 1 | 6.00 |
| CHEMBL338109 | — | — | 1 | 5.55 |
| CHEMBL420516 | — | — | 1 | 5.36 |
| CHEMBL70380 | — | — | 1 | 5.00 |
| CHEMBL338217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332826 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL126716 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL16900 | L-768673 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL127701 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL441474 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL340353 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL127661 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL443550 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL126421 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL339327 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL331861 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL127423 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL341044 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL330992 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL124092 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL124993 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL9387 | L-365260 | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL124306 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL128007 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL128031 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL330970 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL338109 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL420516 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL70380 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL338217 | — | IC50 | > | 10000.0 | nM | - |