Assay Detail
Functional
CHEMBL686967
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Inhibition of human HCT(colon) carcinoma cell proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.64 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.07 |
| CHEMBL338264 | — | — | 1 | 5.98 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.76 |
| CHEMBL126545 | — | — | 1 | 5.52 |
| CHEMBL332575 | — | — | 1 | 5.30 |
| CHEMBL421087 | — | — | 1 | 5.23 |
| CHEMBL127532 | — | — | 1 | - |
| CHEMBL338289 | — | — | 1 | - |
| CHEMBL340685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL338264 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL126545 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL332575 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL421087 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL127532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338289 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340685 | — | IC50 | > | 10000.0 | nM | - |