Assay Detail
Functional
CHEMBL686995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Equilibrium dissociation constant muscarinic receptor complex, measured in guinea pig ileum
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 24 | 5.24 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420268 | — | — | 1 | 6.82 |
| CHEMBL310852 | — | — | 1 | 6.62 |
| CHEMBL348504 | — | — | 1 | 6.55 |
| CHEMBL434461 | — | — | 1 | 6.36 |
| CHEMBL154455 | — | — | 1 | 6.24 |
| CHEMBL154627 | — | — | 1 | 5.80 |
| CHEMBL11081 | — | — | 1 | 5.66 |
| CHEMBL154092 | — | — | 1 | 5.51 |
| CHEMBL346737 | — | — | 1 | 5.30 |
| CHEMBL346662 | — | — | 1 | 5.27 |
| CHEMBL346955 | — | — | 1 | 5.14 |
| CHEMBL346237 | — | — | 1 | 5.09 |
| CHEMBL348172 | — | — | 1 | 5.07 |
| CHEMBL155263 | — | — | 1 | 4.89 |
| CHEMBL152593 | — | — | 1 | 4.81 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.81 |
| CHEMBL347730 | — | — | 1 | 4.80 |
| CHEMBL152594 | — | — | 1 | 4.75 |
| CHEMBL352248 | — | — | 1 | 4.67 |
| CHEMBL348075 | — | — | 1 | 4.18 |
| CHEMBL154320 | — | — | 1 | 4.17 |
| CHEMBL157438 | — | — | 1 | 4.04 |
| CHEMBL157439 | — | — | 1 | 4.02 |
| CHEMBL154642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420268 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL310852 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL348504 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL434461 | — | Kd | = | 440.0 | nM | 6.36 |
| CHEMBL154455 | — | Kd | = | 570.0 | nM | 6.24 |
| CHEMBL154627 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL11081 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL154092 | — | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL346737 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL346662 | — | Kd | = | 5400.0 | nM | 5.27 |
| CHEMBL346955 | — | Kd | = | 7200.0 | nM | 5.14 |
| CHEMBL346237 | — | Kd | = | 8200.0 | nM | 5.09 |
| CHEMBL348172 | — | Kd | = | 8600.0 | nM | 5.07 |
| CHEMBL155263 | — | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL152593 | — | Kd | = | 15600.0 | nM | 4.81 |
| CHEMBL14 | CARBACHOL | Kd | = | 15400.0 | nM | 4.81 |
| CHEMBL347730 | — | Kd | = | 15900.0 | nM | 4.80 |
| CHEMBL152594 | — | Kd | = | 17900.0 | nM | 4.75 |
| CHEMBL352248 | — | Kd | = | 21600.0 | nM | 4.67 |
| CHEMBL348075 | — | Kd | = | 65600.0 | nM | 4.18 |
| CHEMBL154320 | — | Kd | = | 68000.0 | nM | 4.17 |
| CHEMBL157438 | — | Kd | = | 91900.0 | nM | 4.04 |
| CHEMBL157439 | — | Kd | = | 95400.0 | nM | 4.02 |
| CHEMBL154642 | — | Kd | = | 208000.0 | nM | - |