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Assay Detail

CHEMBL687091

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Functional
Inhibitory concentration against HCT116 cells proliferation
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Expert

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Histone deacetylase inhibitors.
Miller TA, Witter DJ, Belvedere S.
J Med Chem (2003) 46 : 5097 -5116
PubMed 14613312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.49 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL356066 DACINOSTAT 2.0 1 8.00
CHEMBL342474 1 7.19
CHEMBL27556 1 6.16
CHEMBL149444 1 6.00
CHEMBL26844 1 5.50
CHEMBL346414 1 5.46
CHEMBL148313 1 5.40
CHEMBL148968 1 5.40
CHEMBL275380 1 5.33
CHEMBL26518 1 5.18
CHEMBL283439 1 5.03
CHEMBL28280 1 5.01
CHEMBL149172 1 4.82
CHEMBL285793 1 4.68
CHEMBL433820 1 4.65
CHEMBL283698 1 4.04
CHEMBL280792 1 -
CHEMBL359303 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL356066 DACINOSTAT IC50 = 10.0 nM 8.00
CHEMBL342474 IC50 = 64.0 nM 7.19
CHEMBL27556 IC50 = 700.0 nM 6.16
CHEMBL149444 IC50 = 1000.0 nM 6.00
CHEMBL26844 IC50 = 3200.0 nM 5.50
CHEMBL346414 IC50 = 3500.0 nM 5.46
CHEMBL148313 IC50 = 4000.0 nM 5.40
CHEMBL148968 IC50 = 4000.0 nM 5.40
CHEMBL275380 IC50 = 4700.0 nM 5.33
CHEMBL26518 IC50 = 6600.0 nM 5.18
CHEMBL283439 IC50 = 9400.0 nM 5.03
CHEMBL28280 IC50 = 9700.0 nM 5.01
CHEMBL149172 IC50 = 15000.0 nM 4.82
CHEMBL285793 IC50 = 20900.0 nM 4.68
CHEMBL433820 IC50 = 22500.0 nM 4.65
CHEMBL283698 IC50 = 90100.0 nM 4.04
CHEMBL280792 IC50 = 112500.0 nM -
CHEMBL359303 IC50 = - nM -