Assay Detail
Functional
CHEMBL687093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HCT116 colon cancer cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.42 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151831 | — | — | 1 | 7.40 |
| CHEMBL151336 | — | — | 1 | 6.80 |
| CHEMBL346445 | — | — | 1 | 6.77 |
| CHEMBL151313 | — | — | 1 | 6.75 |
| CHEMBL348438 | — | — | 1 | 6.38 |
| CHEMBL356649 | — | — | 1 | 6.26 |
| CHEMBL345312 | — | — | 1 | 6.21 |
| CHEMBL356208 | — | — | 1 | 6.18 |
| CHEMBL150994 | — | — | 1 | 6.14 |
| CHEMBL415735 | — | — | 1 | 6.09 |
| CHEMBL149352 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151831 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL151336 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL346445 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL151313 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL348438 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL356649 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL345312 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL356208 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL150994 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL415735 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL149352 | — | IC50 | = | 2220.0 | nM | 5.65 |