Assay Detail
Functional
CHEMBL687102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against HL-60 leukemia cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.32 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608256 | 2-(9-acridiniumylamino)ethyl(methyl)amino(imino)methyl(methyl)amine1-PtCl(en) | — | 1 | 6.89 |
| CHEMBL352708 | — | — | 1 | 4.96 |
| CHEMBL608255 | 9-acridinylmethylamino-methylaminomethanethione1-PtCl(en) | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608256 | 2-(9-acridiniumylamino)ethyl(methyl)amino(imino)methyl(methyl)amine1-PtCl(en) | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL352708 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL608255 | 9-acridinylmethylamino-methylaminomethanethione1-PtCl(en) | IC50 | = | 75000.0 | nM | 4.12 |