Assay Detail
Functional
CHEMBL687154
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Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
8,11-dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug-resistant cell lines: synthesis and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.95 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 9.09 |
| CHEMBL418866 | — | — | 1 | 8.78 |
| CHEMBL116091 | — | — | 1 | 8.18 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.11 |
| CHEMBL116415 | — | — | 1 | 8.08 |
| CHEMBL119334 | — | — | 1 | 7.93 |
| CHEMBL119703 | — | — | 1 | 7.84 |
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 7.80 |
| CHEMBL116295 | — | — | 1 | 7.78 |
| CHEMBL118423 | — | — | 1 | 7.68 |
| CHEMBL334256 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL418866 | — | IC50 | = | 1.67 | nM | 8.78 |
| CHEMBL116091 | — | IC50 | = | 6.62 | nM | 8.18 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL116415 | — | IC50 | = | 8.38 | nM | 8.08 |
| CHEMBL119334 | — | IC50 | = | 11.68 | nM | 7.93 |
| CHEMBL119703 | — | IC50 | = | 14.45 | nM | 7.84 |
| CHEMBL49442 | AMETANTRONE | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL116295 | — | IC50 | = | 16.58 | nM | 7.78 |
| CHEMBL118423 | — | IC50 | = | 21.04 | nM | 7.68 |
| CHEMBL334256 | — | IC50 | = | 587.0 | nM | 6.23 |