Assay Detail
Functional
CHEMBL687174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZAT (mer+)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor imidazotetrazines. 41. Conjugation of the antitumor agents mitozolomide and temozolomide to peptides and lexitropsins bearing DNA major and minor groove-binding structural motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435951 | MITOZOLOMIDE | 2.0 | 1 | 4.52 |
| CHEMBL153371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435951 | MITOZOLOMIDE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL153371 | — | IC50 | > | 500000.0 | nM | - |