Assay Detail
Functional
CHEMBL687203
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Compound was evaluated for cytotoxicity against H.Ep.-2 cells, and concentration required to inhibit the growth of treated cells to 50% of untreated control.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEp-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- (1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol, the carbocyclic analogue of tubercidin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.53 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | — | 1 | 8.70 |
| CHEMBL63261 | — | — | 1 | 6.22 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 6.16 |
| CHEMBL151247 | — | — | 1 | 5.85 |
| CHEMBL202701 | — | — | 1 | 5.70 |
| CHEMBL356894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL63261 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL477 | ADENOSINE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL151247 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL202701 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL356894 | — | IC50 | > | 70000.0 | nM | - |