Compound Detail
CHEMBL151247
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Basic Information
| ChEMBL ID | CHEMBL151247 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWEFPWLRKOSAMD-OGRPXKOKSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
264.3
MW (Da)
-0.71
ALogP
7
HBA
4
HBD
117.4
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.85
Ki 1 meas. best 4.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HEp-2 CHEMBL614735 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| L1210 (1565) CHEMBL614000 | IC50 | 5.4 | 5.4 | 4000.0 | 1 |
| L1210 (1565) CHEMBL614000 | Ki | 4.36 | 4.36 | 44000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HEp-2 | IC50 | = | 1400.0 | nM | 5.85 | Compound was evaluated for cytotoxicity against H.Ep.-2 cells, and concentration... | 6708054 |
| L1210 (1565) | IC50 | = | 4000.0 | nM | 5.4 | Compound was evaluated for cytotoxicity against L-1210 cells, and concentration ... | 6708054 |
| L1210 (1565) | Ki | = | 44000.0 | nM | 4.36 | Compound was evaluated for cytotoxicity against L-1210 (AK-) cells, and concentr... | 6708054 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6708054 | 10.1021/jm00370a018 | L1210 (1565) | 3 |
| 6708054 | 10.1021/jm00370a018 | HEp-2 | 1 |
Data from ChEMBL 36 via Core Engine