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Assay Detail

CHEMBL702592

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for cytotoxicity against L-1210 cells, and concentration required to inhibit the growth of treated cells to 50% of untreated control.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210 (1565)
Confidence 1 — Organism
Curated By Intermediate

Target

L1210 (1565) (CHEMBL614000)
Type CELL-LINE

Publication

(+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- (1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol, the carbocyclic analogue of tubercidin.
Secrist JA, Clayton SJ, Montgomery JA.
J Med Chem (1984) 27 : 534 -536
PubMed 6708054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.40 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL63261 1 5.40
CHEMBL151247 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL63261 IC50 = 4000.0 nM 5.40
CHEMBL151247 IC50 = 4000.0 nM 5.40