Assay Detail
Functional
CHEMBL687246
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Tested for the cytostatic activity as inhibitory concentration against leukemia HL-60 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.75 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3037825 | — | — | 1 | 9.92 |
| CHEMBL2368219 | — | — | 1 | 9.70 |
| CHEMBL2368216 | — | — | 1 | 9.62 |
| CHEMBL2368220 | — | — | 1 | 9.60 |
| CHEMBL2368217 | — | — | 1 | 9.54 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.14 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.92 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.60 |
| CHEMBL2368221 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3037825 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL2368219 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2368216 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL2368220 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL2368217 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2368221 | — | IC50 | = | 190.0 | nM | 6.72 |