Assay Detail
Functional
CHEMBL687331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
58
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 4.60 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1907728 | — | — | 1 | 5.30 |
| CHEMBL1907719 | — | — | 1 | 5.24 |
| CHEMBL51569 | — | — | 1 | 4.92 |
| CHEMBL1907717 | — | — | 1 | 4.89 |
| CHEMBL1907720 | — | — | 1 | 4.89 |
| CHEMBL1907734 | — | — | 1 | 4.89 |
| CHEMBL429063 | — | — | 1 | 4.85 |
| CHEMBL20408 | — | — | 1 | 4.85 |
| CHEMBL2092989 | — | — | 1 | 4.75 |
| CHEMBL1907731 | — | — | 1 | 4.68 |
| CHEMBL1907743 | — | — | 1 | 4.64 |
| CHEMBL1907735 | — | — | 1 | 4.62 |
| CHEMBL1907733 | — | — | 1 | 4.60 |
| CHEMBL1907730 | — | — | 1 | 4.60 |
| CHEMBL1907738 | — | — | 1 | 4.55 |
| CHEMBL70728 | — | — | 1 | 4.52 |
| CHEMBL1907736 | — | — | 1 | 4.42 |
| CHEMBL1907714 | — | — | 1 | 4.40 |
| CHEMBL1907729 | — | — | 1 | 4.31 |
| CHEMBL1907740 | — | — | 1 | 4.30 |
| CHEMBL1907737 | — | — | 1 | 4.24 |
| CHEMBL1907724 | — | — | 1 | 4.17 |
| CHEMBL1907931 | — | — | 1 | 4.16 |
| CHEMBL1907739 | — | — | 1 | 4.10 |
| CHEMBL2092748 | — | — | 1 | 4.00 |
| CHEMBL1907721 | — | — | 1 | - |
| CHEMBL1907742 | — | — | 1 | - |
| CHEMBL2092990 | — | — | 1 | - |
| CHEMBL1907718 | — | — | 1 | - |
| CHEMBL20223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1907728 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1907719 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL51569 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1907717 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1907720 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1907734 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL20408 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL429063 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2092989 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1907731 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1907743 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1907735 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1907733 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1907730 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1907738 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL70728 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1907736 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1907714 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1907729 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1907740 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1907737 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL1907724 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL1907931 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1907739 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2092748 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2092988 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907932 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL21770 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL279237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907930 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL430336 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2092746 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907715 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907722 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2092746 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL1907727 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907741 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907718 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907721 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907716 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907742 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20872 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2092990 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL20223 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3350230 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL552817 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20683 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL1907723 | — | IC50 | > | 100000.0 | nM | - |