Assay Detail
Functional
CHEMBL687456
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Compound was evaluated for kappa opioid receptor mediated agonistic effect in electrically stimulated guinea-pig ileum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
6N-Cinnamoyl--naltrexamine and its p-nitro derivative. High efficacy -opioid agonists with weak antagonist actions
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.46 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473362 | — | — | 1 | 9.40 |
| CHEMBL296693 | — | — | 1 | 8.66 |
| CHEMBL297756 | — | — | 1 | 7.90 |
| CHEMBL417535 | — | — | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473362 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL296693 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL297756 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL417535 | — | IC50 | = | 13.4 | nM | 7.87 |