Assay Detail
Functional
CHEMBL687469
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Inhibition of HCT116 colon carcinoma cell proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.99 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149096 | — | — | 1 | 7.54 |
| CHEMBL148638 | — | — | 1 | 7.39 |
| CHEMBL356728 | — | — | 1 | 7.19 |
| CHEMBL148995 | — | — | 1 | 7.13 |
| CHEMBL358525 | — | — | 1 | 6.96 |
| CHEMBL149450 | — | — | 1 | 6.92 |
| CHEMBL151546 | — | — | 1 | 6.89 |
| CHEMBL148669 | — | — | 1 | 6.85 |
| CHEMBL359200 | — | — | 1 | 6.54 |
| CHEMBL150867 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149096 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL148638 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL356728 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL148995 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL358525 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL149450 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL151546 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL148669 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL359200 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL150867 | — | IC50 | = | 360.0 | nM | 6.44 |