Assay Detail

CHEMBL687544

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Binding

Inhibition of human recombinant Gelatinase B (MMP-9)

ChEMBL ↗

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Target

Matrix metalloproteinase-9 (CHEMBL321) ↗

Open DB target context

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Primary target Matrix metalloproteinase-9

CHEMBL321

Anchored from Assay target.

Protein identity Matrix metalloproteinase-9

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Matrix metalloproteinase-9 (CHEMBL321) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Inhibition of Matrix Metalloproteinases: An examination of the S1 pocket

Miller A, Askew M, Beckett R, Bellamy CL, Bone EA, Coates RE, Davidson AH, Drummond AH, Huxley P, Martin FM, Saroglou L, Thompson AJ, van Dijk SE, Whittaker M
Bioorg Med Chem Lett (1997) 7 : 193 -198
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.82	8.82

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL59338	—	—	1	8.82

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL59338	—	IC50	=	1.5	nM	8.82